84-2377-89　［取扱停止］PCGF6 (MBLR, Mel18 and Bmi1 like RING Finger Protein, Mel18 and Bmi1-like RING Finger, PCGF6, PCGF6_HUMAN, Polycomb group RING Finger Protein 6, RING Finger Protein 134, RNF134) 100ul　224905

特徴

• Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes.
• Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins.
• The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms.
• Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation.
• PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger.
• PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase.
• PCGF6 exists as two alternatively spliced isoforms.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.