84-2377-87　［取扱停止］PCGF1 (Polycomb group RING Finger Protein 1, Nervous system Polycomb-1, NSPc1, RING Finger Protein 68, PCGF1, NSPC1, RNF68) 100ul　224904

特徴

• Polycomb group (PCG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes.
• Several PCG proteins contain ring finger domains and have been identified as a subclass of RING finger proteins.
• The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms.
• Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation.
• PCGF1 (polycomb group ring finger 1), also known as NSPC1, RNF68 or RNF3A-2, is a 259 amino acid nuclear protein that is ubiquitously expressed.
• PCGF1 is a component of the PCG multiprotein BCoR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as Bcl-6 and the cyclin-dependent kinase inhibitor, p21.
• PCGF1 promotes cell cycle progression and enhances cell proliferation.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.