p140Cap, also known as P140, KIAA1684 or SNIP (SNAP25-interacting protein), is a 1,055 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and exists as multiple alternatively spliced isoforms.
Interacting with the N-terminal region of SNAP 25, p140Cap functions to delay the onset of cell spreading during the early stages of cell adhesion and may also be involved in calcium-dependent exocytosis from specific cell types.
The gene encoding p140Cap maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.
Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of p140Cap. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 810-862 of Human p140Cap.
