84-2374-33　［取扱停止］p130 Cas, phosphorylated (Y249) (Breast Cancer anti-Estrogen Resistance Protein 1, CRK-Associated Substrate, Cas Scaffolding Protein Family Member 1, p130cas, BCAR1, CAS, CASS1, CRKAS) 50ul　224728

特徴

• The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins.
• p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple yXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection.
• Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.