84-2374-23　［取扱停止］OXSR1 (Serine/threonine-Protein Kinase OSR1, Oxidative stress-responsive 1 Protein, KIAA1101, OSR1) 50ul　224723

特徴

• Oxidative stress-responsive 1 protein (OXSR1), a protein of 527 amino acids, belongs to the STE20 subfamily.
• OXSR1 is one of two human homologs of Fray, a serine/threonine kinase expressed in Drosophila.
• OXSR1 binds to and phosphorylates p21-activated protein kinase PAK1 and regulates downstream kinases in response to environmental stress.
• Endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl.
• OXSR1 may also play a role in regulating the actin cytoskeleton.
• The chloride channel proteins SLC12A1, SLC12A2, and SLC12A6 isoform 2 interact with OXSR1, but SLC12A4 and SLC12A7 do not.
• The WNK1 and WNK4 protein kinases activate OXSR1 by phosphorlating its T-loop.
• The OXSR1 protein is widely expressed in mammalian tissues.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.