This gene encodes the coiled-coil containing protein optineurin.
Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma.
Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction.
Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.
Alternative splicing results in multiple transcript variants encoding the same protein.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of OPTN. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human OPTN.
Shelf Life：1year
Swiss Prot Number：Q96CV9
EU Commodity Code：30021010
商品名：OPTN (14.7K interacting Protein, Ag9 C5, ALS12, E3 14.7K interacting Protein, E3-14.7K-interacting Protein, FIP 2, FIP-2, FIP2, Glaucoma 1 open angle E (adult onset), Glaucoma 1 open angle E, GLC1E, HIP 7, HIP-7, HIP7, Huntingtin interacting Protein 7, Huntingtin interacting Protein HYPL, Huntingtin interacting Protein L, Huntingtin yeast Partner L, Huntingtin-interacting Protein 7, Huntingtin-interacting Protein L, HYPL, Injury inducible Protein I 55, NEMO Related Protein, NEMO-Related Protein, NRP, Optic neuropathy inducing Protein, Optic neuropathy-inducing Protein, Optineurin, OPTN, OPTN_HUMAN, TFIIIA IntP, TFIIIA-IntP, Transcription Factor IIIA interacting Protein, Transcription Factor IIIA-interacting Protein, Tumor Necrosis Factor alpha inducible Cellular Protein Containing Leucine Zipper Domains,) 50ul
