Endogenous opioid peptides and opiates like morphine mediate their cellular effects through membrane bound receptors.
Three different types of opioid receptors have been identified, mu-type, delta-type and kappa-type.
A fourth opioid receptor, KOR-3 (kappa-type opioid receptor, also designated ORL1- Opioid Receptor Like 1), has been identified.
Though closely related genetically to the other opioid receptors, KOR-3 has a distinct pharmacological profile.
Nociceptin, the neuropeptide which activates KOR-3, is structurally similar to the kappa-opioid peptide dynorphin A, but quite different in its mode of interaction with its receptor.
KOR-3 is widely expressed in the nervous system, and is likely to modulate a broad range of physiological and behavioral functions.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of OPRL1. Species Crossreactivity: Human, mouse, rat
