POU homeodomain proteins are transcriptional regulators that function in various developmental processes (e.g.
cell division, differentiation, specification and survival of specific cell types) and participate in the determination of cell fate.
The 45kDa POU transcription factor Oct-6 (also designated SCIP and Tst-1) is expressed by late embryonic Schwann cells of the peripheral nervous system and is also expressed by nonmyelinating Schwann cells in adults.
Oct-6 is strongly upregulated in promyelin cells because it is required for the timely differentiation of promyelin cells into myelinating cells.
Oct-6 functions during myelination and is required for the proper downregulation of its own gene when myelination proceeds.
c-Myc can act synergistically with the POU domain of Oct-6 to produce myelin disease pathogenesis in the mammalian central nervous system.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Oct-6. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 300-350 of Human Oct-6.
