The antizyme family is a group of small proteins that play a role in cell growth and division by regulating the biosynthesis of polyamines such as putrescine, spermidine and spermine.
AZ3, also known as OAZ3 (Ornithine decarboxylase antizyme 3), is a 187 amino acid protein that belongs to the ODC antizyme family.
AZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells because it binds to, and destabilizes, ornithine decarboxylase.
However, mutations in the AZ3 gene are not a common cause of male infertility and the normal AZ3 protein does not accelerate ornithine decarboxylase degeneration.
AZ3 expression has a sharp onset in early spermatids, peaks in later stages and is gone in spermatozoa.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of OAZ3. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human OAZ3.
