The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3).
Trk B is a tyrosine kinase gene highly related to Trk A.
Trk B expression is confined to tissues within the central and peripheral nervous systems.
The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on Tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3.
Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3.
The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3.
Four forms of Trk C are produced by alternative splicing.
Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839.
Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of NTRK3. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human NTRK3.
Shelf Life：1year
Swiss Prot Number：Q16288
EU Commodity Code：30021010
商品名：NTRK3 (ETS Related Protein Neurotrophic Receptor Tyrosine Kinase Fusion, ETV6 NTRK3 Fusion, GP145 TrkC, gp145(trkC), GP145-TrkC, GP145TrkC, Neurotrophic Tyrosine Kinase Receptor Type 3, neurotrophin 3 Receptor, NT 3 Growth Factor Receptor, NT 3 Growth Factor Receptor Precursor, NT 3 Receptor, NT-3 Growth Factor Receptor, NTRK3, NTRK3_HUMAN, OTTHUMP00000192915, TRK C, Trk-C, TrkC Tyrosine Kinase, Tyrosine Kinase Receptor C) 50ul
