84-2372-65　［取扱停止］NRXN3 (Neurexin-3, Neurexin III-alpha, Neurexin-3-alpha, NRXN3, C14orf60, KIAA0743) 50ul　224643

特徴

• Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV).
• Neurexins I-III are expressed as a and b isoforms.
• The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal.
• The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin.
• The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes.
• Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin.
• Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons.
• Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region.
• Caspr may play a role in the communication of glial cells and neurons during development.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.