84-2372-57　［取扱停止］NRG1 (Acetylcholine Receptor inducing activity, Acetylcholine Receptor-inducing activity, ARIA, Breast Cancer Cell Differentiation Factor p45, ERBB2 p185 Activator, GGF 2, GGF, GGF2, Glial Growth Factor, Heregulin alpha, Heregulin, heregulin, alpha (45, ERBB2 p185-Activator), HGL, HRG 1, HRG, HRG1, HRGA, MST131, NDF, Neu Differentiation Factor, Neuregulin 1, neure ...　224639

特徴

• Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites.
• Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function.
• Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution.
• Six types of Neuregulin-1 isoform groups have been defined based on their structural features.
• Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF).
• Neuregulin-1 has been linked to schizophrenia and has diverse neural functions.
• Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.