NR5A2 (nuclear receptor subfamily 5, group A, member 2), also designated B1-binding factor (B1F or B1F2), CYP7A promoter-binding factor (CPF), fetoprotein-alpha 1 (AFP) transcription factor (FTF, FTZ-F1 or FTZ-F1beta) and liver receptor homolog 1 (LRH-1), is a pre-adipocyte-specific nuclear receptor that regulates expression of aromatase in adipose tissue.
NR5A2 belongs to the fushi tarazu factor-1 subfamily of orphan nuclear receptors.
NR5A2 transcripts are abundant in the human ovary and testis and are predominantly expressed in tissues of endodermal origin.
NR5A2 is a positive transcription factor for ABCG5 and ABCG8 and regulates genes involved in sterol and bile acid secretion from liver and intestine.
It induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of NR5A2. Species Crossreactivity: Human, mouse, rat
