The cooperation of liver X receptors (LXRs) alpha and beta and retinoic X receptor (RXR) modulate the expression of several genes involved in lipid metabolism in hepatocyte and macrophages.
RXR is the receptor for 9-cis retinoic acid and dimerizes with VDR, TR, PPAR and several novel receptors including liver X receptors LXRalpha (also referred to as RLD-1), LXRbeta and FXR.
FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand.
Both LXR/ RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
LXRalpha and LXRbeta share considerable sequence homology and several functions, respond to the same endogenous levels of and synthetic ligands and play critical roles in maintaining lipid homeostasis.
LXRbeta is ubiquitously expressed and enriched in tissues of neuronal and endocrine origin.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of NR1H3. Species Crossreactivity: Human, mouse, rat
