84-2372-21　［取扱停止］NQO1 (NAD(P)H Dehydrogenase [quinone] 1, AzoReductase, DT-diaphorase, DTD, Menadione Reductase, NAD(P)H:quinone oxidoReductase 1, Phylloquinone Reductase, Quinone Reductase 1, QR1, NQO1, DIA4, NMOR1) 50ul　224621

特徴

• NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the two-electron reduction of quinones and their derivatives.
• This enzyme protects cells against redox cycling and oxidative stress.
• The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues.
• Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQ01 in the prevention of tumor development.
• Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turns leads to myeloid hyperplasia of bone marrow.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.