Pancreatic polypeptide (PP), neuropeptide y (NPy), and peptide yy (Pyy) are related 36-amino acid hormones.
A number of structurally related receptors for these peptides have been isolated, NPy1-R, NPy2-R, NPy3-R, NPy4-R,NPy5-R, and NPy6-R.
NPy4-R is expressed in several human tissues, including brain, coronary artery, and ileum.
NPy4-R maps to human chromosome 10q11.2-q21.2.
NPy-5R, isolated from rat hypothalamus, encodes a 456-amino acid protein with less than 35% overall identity to known y-type receptors.
The human NPy-5R sequence is nearly identical to, but in the opposite orientation from, that of the human NPy-1R sequence.
NPy5-R localizes to the paraventricular hypothalamic nucleus, the lateral hypothalamus, and other locations consistent with a role in the control of feeding behavior.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of NPY5-R. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 230-286 of Human NPY5-R.
