84-2371-89　［取扱停止］NPAS2 (Neuronal PAS Domain-Containing Protein 2, Neuronal PAS2, Basic-helix-loop-helix-PAS Protein MOP4, Class E basic Helix-Loop-Helix Protein 9, bHLHe9, Member of PAS Protein 4, PAS Domain-Containing Protein 4, NPAS2, BHLHE9, MOP4, PASD4) 100ul　224604

特徴

• Members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family are transcription factors that contain a bHLH DNA binding domain located amino-terminal to a PAS domain.
• Neuronal PAS domain protein 2 (NPAS2, also designated PAS 4/MOP4) is a member of the bHLH-PAS family and the PAS superfamily.
• NPAS2, which maps to chromosome 2p11.2-2q13, is expressed primarily in the neurons during the first week of postnatal development.
• The pattern of NPAS2 expression temporally matches the development of learning and memory, and spatially matches the frontal association/limbic forebrain pathway.
• NPAS2 may serve a regulatory role in the development and maintenance of long-term memory, and may be required for the processing of complex sensory information.
• NPAS2 and MOP3 form a transcriptionally active heterodimer which binds to a CACGTGA-containing DNA element and drives transcription from a linked luciferase reporter gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.