84-2371-87　［取扱停止］NPAS1 (Neuronal PAS Domain-Containing Protein 1, Neuronal PAS1, Basic-helix-loop-helix-PAS Protein MOP5, Class E basic Helix-Loop-Helix Protein 11, bHLHe11, Member of PAS Protein 5, PAS Domain-Containing Protein 5, BHLHE11, MOP5, PASD5) 100ul　224603

特徴

• Members of the bHLH-PAS family are transcription factors that contain a basic helix-loop-helix (bHLH) DNA-recognition motif which is located N-terminal to a PAS domain comprised of two imperfect direct repeats.
• Human NPAS1 is a deduced 590-amino acid protein which shares 86% sequence homology with mouse Npas1.
• In order for NPAS1 to bind DNA efficiently, it must form a dimer with another bHLH protein.
• NPAS1 interacts with ARNT (aryl hydrocarbon receptor nuclear translocator), and shows predominant expression in brain tissue.
• NPAS1 is also implicated in the control of regulatory pathways relevant to schizophrenia and to psychotic illness, and may play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen levels.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.