Induces NF-kappa-B activity via RIPK2 and IKK-gamma.
Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).
Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens.
Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion.
Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of NOD1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human NOD1.
Shelf Life：1year
Swiss Prot Number：Q9Y239
EU Commodity Code：30021010
商品名：NOD1 (CARD 4, CARD4, Caspase Recruitment Domain 4, Caspase Recruitment Domain Containing Protein 4, Caspase Recruitment Domain Family Member 4, Caspase Recruitment Domain Protein 4, Caspase Recruitment Domain-Containing Protein 4, CLR 7.1, CLR7.1, NLR Family CARD Domain Containing 1, NLRC 1, NLRC1, NOD 1, Nod1, NOD1 Protein, NOD1, Nucleotide Binding oligomerization Domain Containing 1, Nucleotide Binding oligomerization Domain Leucine Rich Repeat and CARD Domain Containing 1, N) 100ul
