84-2371-21　［取扱停止］NMDA zeta1 (Glutamate Receptor Ionotropic, NMDA 1, GluN1, Glutamate [NMDA] Receptor Subunit zeta-1, N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, GRIN1, NMDAR1) 100ul　224570

特徴

• NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium.
• Mediated by glycine.
• Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning.
• It mediates neuronal functions in glutamate neurotransmission.
• Is involved in the cell surface targeting of NMDA receptors.
• The ion channels activated by glutamate are divided into two classes.
• Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR).
• NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.