84-2371-13　［取扱停止］NMDA epsilon4 (Glutamate Receptor Ionotropic, NMDA 2D, GluN2D, EB11, Glutamate [NMDA] Receptor Subunit epsilon-4, N-methyl D-aspartate Receptor subtype 2D, Short name=NMDAR2D, Short name=NR2D, GRIN2D, GluN2D, NMDAR2D) 100ul　224566

特徴

• Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration.
• Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels.
• Kainate/AMPA receptors are colocalized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7.
• The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions.
• The NMDA receptors consist of five subunits: ε 1, 2, 3, 4 and one zeta subunit.
• The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.