NMB (neuromedin-B) is a 121 amino acid secreted protein that belongs to the bombesin/neuromedin-B/ranatensin family and exists as two alternatively spliced isoforms.
Acting in a manner similar to that of bombesin, NMB stimulates smooth muscle contraction.
The gene that encodes NMB consists of about 3,443 bases and maps to human chromosome 15q25.
Housing ~106 million base pairs and encoding more than 700 genes, chromosome 15 makes up about 3% of the human genome.
Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region.
Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15.
Marfan syndrome is associated with chromosome 15 through the FBN1 gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of NMB. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human NMB.
