The lecticans are a family of chondroitin proteoglycans, including aggrecan, versican, neurocan and brevican, that contain a C-type lectin domain.
Neurocan is a glycoprotein synthesized primarily by neurons, and its expression levels are highest during embryonic brain development and during the early postnatal period.
Neurocan is a component of the extracellular matrix in the central nervous system that can bind to various other CNS matrix components, such as heparin, Tenascin-R, HB-GAM and NCAM, suggesting that it plays a role in axon guidance and neurite growth.
Neurocan is a 1,257 amino acid, precursor protein in embryonic and neonatal rats that is proteolytically proc-essed in the adult CNS into an N-terminal fragment, which localizes to the cytoplasm of glial cells.
Neurocan expression (including the re-expression of the neonatal isoform) increases significantly in adults in the glial scar resulting from cortical injury.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of Neurocan. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 440-485 of Human Neurocan.
