84-2368-65　［取扱停止］NEEP21 (Brain neuron Cytoplasmic Protein 1, Brain specific mRNA b, Bsmrb, Neuron-specific Gene Family Member 1, Neuron-specific Protein Family Member 1, NSG1, NSG1, PEP1, D4S234E) 50ul　224442

特徴

• NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family.
• It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues.
• NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons.
• It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2.
• When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties.
• In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.