84-2368-29　［取扱停止］NDEL1 (A. nidulans, DKFZp451M0318, ENDOOLIGOPEPTIDASE A, EOPA, MITAP 1, MITAP1, Mitosin Associated Protein 1, Mitosin Associated Protein MITAP1, Mitosin-Associated Protein 1, Ndel 1, NDEL1, NDEL1_HUMAN, Nuclear distribution Gene E like Homolog 1, Nuclear distribution Protein nudE like 1, Nuclear distribution Protein nudE-like 1, NUDE like Protein, NudE Nuclear dis ...　224424

特徴

• NudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle.
• It positively regulates minus-end directed dynein.
• Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning.
• Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring.
• Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus.
• Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.