84-2368-03　［取扱停止］NBL1 (Neuroblastoma Suppressor of Tumorigenicity 1, DAN Domain Family Member 1, Protein N03, Zinc Finger Protein DAN, DAN, DAND1) 50ul　224411

特徴

• The DAN (differential screening-selected gene aberrative in neuroblastoma) protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest.
• All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development.
• This family includes the head-inducing factor Cerberus, the dorsaling factor gremlin and the tumor suppressor DAN.
• DAN, also known as zinc finger protein DAN, NO3, DAND1 or neuroblastoma suppressor of tumorigenicity 1 (NBL1), is a secreted protein containing one C-terminal cysteine knot-like (CTCK) domain.
• It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1.
• In addition to antagonizing BMP signaling, DAN also antagonizes the action of TGFbeta.
• DAN is a possible tumor suppressor for human neuroblastoma; defects may result in or contribute to its progression.
• DAN may also be a neuromodulator in inflammatory pain.
• Applications:Suitable for use in Western Blot, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.