84-2367-83　［取扱停止］Na+/K (Sodium/Potassium-transporting ATPase Subunit alpha-2,Na(+)/K(+) ATPase alpha-2 Subunit,Sodium pump Subunit alpha-2,KIAA0778,ATP1A2) 100ul　224401

特徴

• The ubiquitously expressed sodium/potassium-ATPase exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients.
• As a member of the P-type family of ion motives, sodium/potassium-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport.
• Multiple isoforms of three subunits, alpha, beta and ©, comprise to form the sodium/potassium-ATPase oligomer.
• The alpha-subunit contains the binding sites for ATP and the cations.
• The glycosylated beta-subunit ensures correct folding and membrane insertion of the alpha-subunits.
• The small ©-subunit colocalizes with the alpha-subunit in nephron segments where it increases the affinity of sodium/potassium ATPase for ATP.
• The beta-subunit, but not the ©-subunit, is essential for normal activity of sodium/potassium ATPase.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.