84-2367-75　［取扱停止］Na+ CP type VIIIalpha (Sodium Channel Protein Type 8 Subunit alpha, Sodium Channel Protein Type VIII Subunit alpha, Voltage-Gated sodium Channel Subunit alpha Nav1.6, SCN8A, MED) 100ul　224397

特徴

• The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIalpha ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes.
• The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit.
• The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction.
• The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIalpha subunits are more abundant along axons.
• Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development.
• Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons.
• Loss of SCN8A expression will result in progressive paralysis and early death.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.