84-2367-73　［取扱停止］Na+ CP type IXalpha (Sodium Channel Protein Type 9 Subunit alpha, Neuroendocrine sodium Channel, hNE-Na, Peripheral sodium Channel 1, PN1, Sodium Channel Protein Type IX Subunit alpha, Voltage-Gated sodium Channel Subunit alpha Nav1.7, SCN9A, NENA) 100ul　224396

特徴

• Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells.
• During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell.
• Na+ CP type IXalpha, also known as SCN9A (sodium channel protein type 9 subunit alpha), NENA, PN1, Nav1.7 or ETHA, is a 1,988 amino acid multi-pass membrane protein that belongs to the voltage-gated sodium channel family.
• Expressed in dorsal root ganglion, smooth muscle cells and in the central and peripheral nervous system, Na+ CP type IXalpha functions to mediate the voltage-dependent sodium ion permeability of membranes, specifically forming a sodium-selective ion channel through which sodium may pass.
• Via its ability to control the flow of sodium in and out of excitable membranes, Na+ CP type IXalpha plays an important role in the inflammatory pain response.
• Defects in the gene encoding Na+ CP type IXalpha are the cause of primary erythermalgia, autosomal recessive congenital indifference to pain and paroxysmal extreme pain disorder (PEPD), all of which are genetic pain disorders.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.