Voltage-gated Na+ channels regulate the permeability of excitable cells to sodium ions.
During the propagation of an action potential, Na+ channels allow an influx of sodium ions, which rapidly depolarize the cell.
The sodium channel protein is comprised of one alpha subunit and two beta subunits.
The Na+ CP type I and Na+ CP type IIalpha subunits are expressed in adult brain.
Na+ CP type IIIalpha is expressed in embryonic brain, but not in adult brain.
Na+ CP type IIIbeta is a 215 amino acid, single-pass type I membrane protein that modulates sodium channel gating kinetics and inactivates the channel opening more slowly than the Ibeta subunit.
It has an extracellular N-terminal domain, an N-terminal signal sequence, a single membrane-spanning region and a C-terminal cytoplasmic region.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Na+ CP. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 1442-1496 of Human Na+ CP type α-pan.
