84-2367-63　［取扱停止］Na+ CP (Sodium Channel Protein Type 2 Subunit alpha, HBSC II, Sodium Channel Protein brain II Subunit alpha, Sodium Channel Protein Type II Subunit alpha, Voltage-Gated sodium Channel Subunit alpha Nav1.2, SCN2A, NAC2, SCN2A1, SCN2A2) 100ul　224391

特徴

• Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells.
• During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell.
• The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIalpha subunits are more abundant along axons.
• The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle.
• In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei.
• Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.