The EF-hand domain is a twelve amino acid loop motif that is commonly found in proteins that participate in calcium-binding events within the cell.
EF-hand domains generally exist in a pair that, together, form a stable four-helix bundle that enables the binding of calcium ions.
MYL6 (myosin, light chain 6, alkali, smooth muscle and non-muscle), also known as ESMLC, LC17A, LC17B or MLC1SM, is a 151 amino acid protein that contains three EF-hand domains and exists as two alternatively spliced isoforms, designated smooth muscle (MLC3SM) and non-muscle (MLC3NM).
Existing as an alkali light chain component of the hexameric Myosin complex, MYL6 participates in generating the force for cellular movements, thereby playing an important role in overall cellular function.
The gene encoding MYL6 maps to human chromosome 12, which encodes over 1,100 genes and comprises ~4.5% of the human genome.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of MYL6. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 101-146 of Human MYL6.
