84-2366-48　［取扱停止］Mucin 4 (Mucin-4, MUC-4, Ascites sialoglycoprotein, ASGP, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin-4 alpha Chain, Ascites sialoglycoprotein 1, ASGP-1, Mucin-4 beta Chain, Ascites sialoglycoprotein 2, ASGP-2, MUC4) 100ul　224332

特徴

• Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates.
• Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC).
• Mucin 4 protein consists of Mucin 4å, a large amino mucin type subunit, and Mucin 4beta, a transmembrane subunit containing three EGF-like domains.
• The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis.
• Dysregulation of Mucin 4 results in high levels of expression in pancreatic tumors and tumor cell lines.
• Induction of Mucin 4 in pancreatic carcinoma by all-trans-retinoic acid is mediated through the retinoic acid receptor-å signaling pathway.
• TGFbeta2 serves as an interim mediator of this regulated expression.
• Alternative splicing in the 3'-end of the Mucin 4 gene generates at least 12 splice variants, which are characterized as two distinct types, a secreted type and a membrane-associated type.
• Mucin 4 protein acts as a heterodimeric bifunctional cell-surface glycoprotein and forms thick mucous effusion in the diseased middle ear.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.