Microsomal triglyceride transfer protein (MTP), catalyzes the transport of cholesteryl ester, triglyceride and phospholipid between phospholipid surfaces.
MTP is a heterodimer consisting of MTP and PDI (protein disulfide isomerase).
It is required for the secretion of plasma lipoproteins containing apolipoprotein b.
It is negatively regulation by insulin and positively regulated by cholesterol.
MTP, which localizes to the endoplasmic reticulum (ER), is expressed primarily in small intestine and liver, kidney, testis and ovary.
It is not expressed in epithelial cells.
Defects in the MTP gene can cause abetalipoproteinemia (ABL) which is an autosomal recessive lipoprotein metabolism disorder.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of MTTP. Species Crossreactivity: Human, mouse, rat
