84-2365-06　［取扱停止］mPR gamma (Membrane progestin Receptor gamma, mPR gamma, Progestin and adipoQ Receptor Family Member 5, Progestin and adipoQ Receptor Family Member V, MPRG, PAQR5) 50ul　224259

特徴

• The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR).
• This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways.
• Three distinct groups, designated alpha, beta, and gamma, comprise this gene family.
• While all contain 7 transmembrane domains, they show distinct distributions in reproductive, neural, kidney and intestinal tissues.
• These characteristics separate them from nuclear progestin receptors, and instead imply similarity to G-protein coupled receptors.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.