In each of these species, the c-Mos proto-oncogene locus consists of a single exon which encodes Mos, a serine/threonine protein kinase involved in the regulation of the meiotic cell cycle in vertebrate oöcytes.
Mos function during oöcyte maturation is thought to be exerted through the stabilization or activation of the maturation promoting factor (MPF) complex.
While the level of Mos expression is generally low in somatic cells, Mos is expressed at relatively high levels in germ cells.
Mos can efficiently cause oncogenic transformation of somatic cells when ectopically expressed during the G1 phase of the cell cycle.
Mos activates MAPK, possibly through direct phosphorylation of the MAPKK MEK-1.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Mos. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 61-110 of Human Mos.
