MOAP1 (modulator of apoptosis 1) is a 352 amino acid protein encoded by the human gene MOAP1.
MOAP1 belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain.
It is required for death receptor-dependent apoptosis.
When MOAP1 is associated with RASSF1, it promotes a Bax conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
MOAP1 is a homo-dimer and, under normal circumstances, is held in an inactive conformation by an intramolecular interaction.
Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to Bax.
MOAP1 will also bind to Bcl-2 and Bcl-x.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of MOAP1. Species Crossreactivity: Human
