84-2364-76　［取扱停止］MNT (Max-Binding Protein MNT, Class D basic Helix-Loop-Helix Protein 3, bHLHd3, Myc antagonist MNT, Protein ROX, BHLHD3, ROX) 100ul　224243

特徴

• Mnt (Max binding protein), also known as MAD6, ROX, bHLHd3 (class D basic helix-loop-helix protein 3) or MXD6, is a 582 amino acid nuclear protein that forms a complex with Max (Myc-associated factor X) to repress transcription.
• Mnt contains one basic helix-loop-helix (bHLH) domain and is encoded by a gene that maps to human chromosome 17p13.3.
• Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes.
• Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.
• Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.
• Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.