84-2364-73　［取扱停止］Mnk1 (MAP Kinase-interacting Serine/threonine-Protein Kinase 1, MAP Kinase Signal-integrating Kinase 1, Mnk1, MKNK1, MNK1) 50ul　224242

特徴

• The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases.
• In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif.
• Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases.
• These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2.
• Similarly p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK).
• The serine/threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.