84-2364-13　［取扱停止］Mlx (Max-like Protein X, Class D basic Helix-Loop-Helix Protein 13, bHLHd13, Max-like bHLHZip Protein, Protein BigMax, Transcription Factor-like Protein 4, MLX, BHLHD13, TCFL4) 50ul　224212

特徴

• Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox).
• These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis.
• Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max.
• Like Max, Mlx is broadly expressed in many tissues and has a long half-life.
• Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes.
• MondoA forms weak homodimers and preferentially forms heterodimers with Mlx.
• The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B.
• Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.