The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family.
The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias.
MLL2, also designated ALR, exists within a complex of proteins.
MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival.
The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors.
MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes.
MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders.
MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus.
MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression.
The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of MLL5. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human MLL5.
Shelf Life：1year
Swiss Prot Number：Q8IZD2
EU Commodity Code：30021010
商品名：MLL5 (HDCMC04P, Histone lysine N Methyltransferase MLL5, Histone-lysine N-Methyltransferase MLL5, KMT2E, Lysine N Methyltransferase 2E, Lysine N-Methyltransferase 2E, MGC70452, Mll5, MLL5_HUMAN, Myeloid/Lymphoid or mixed lineage Leukemia 5 (trithorax Homolog, Drosophila), Myeloid/Lymphoid or mixed lineage Leukemia 5, Myeloid/Lymphoid or mixed lineage Leukemia Protein 5, Myeloid/Lymphoid or mixed-lineage Leukemia Protein 5) 50ul
