MIPP (multiple inositol polyphosphate phosphatase) is the only enzyme that is solely responsible for a diverse range of catalytic activities, including the hydrolysis of inositol pentakisphosphate and inositol hexakisphosphate.
The structural and functional similarity of MIPP to the chick protein HiPER1 (histidine acid phosphatase) reveals that MIPP contains the catalytic requirement of histidine acid phosphatases.
The evolutionary conservation of MIPP in mouse (also called (MMU)Minpp1), human (also called (HSA)MINPP1), chick, plant and fruit fly within the histidine phosphatase family suggests a significant role for multiple inositol polyphosphatase throughout higher eukaryotes.
MIPP is mapped to a region of chromosome 10 that is often mutated in human cancers.
Its carboxy terminal domain contains a signal for retaining soluble proteins in the lumen of the endoplasmic reticulum.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of MIPP. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 330-382 of Human MIPP.
