MFN2 is an essential transmembrane GTPase which mediates mitochondrial fusion.
Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission.
MFN2 acts independently of the cytoskeleton, plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes.
Overexpression induces the formation of mitochondrial networks.
It plays an important role in the regulation of vascular smooth muscle cell proliferation.
Defects in MFN2 lead to Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Mfn2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 381-430 of Human Mfn2.
