84-2363-10　［取扱停止］MerTK (c MER, c mer proto Oncogene Tyrosine Kinase, c-mer, cMER, cmer protoOncogene Tyrosine Kinase, Eyk, MER, MER Receptor Tyrosine Kinase, MERK, MERPEN, Mertk, MERTK c-mer proto-Oncogene Tyrosine Kinase, MERTK_HUMAN, MGC133349, nmf12, Nyk, Proto Oncogene Tyrosine Protein Kinase MER, Proto Oncogene Tyrosine Protein Kinase MER Precursor, Proto-Oncogene c-Mer, Rece ...　224159

特徴

• MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family.
• It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulin-like C2-type domains.
• MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk.
• This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells.
• Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process.
• Evidence suggests that MerTK signals via interaction with phosphatidylinositol- specific phospholipase C y2 (PI-PLC y2).
• When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.