84-2361-55　［取扱停止］MDM4 (Protein Mdm4, Double minute 4 Protein, Mdm2-like p53-Binding Protein, Protein Mdmx, p53-Binding Protein Mdm4, MDM4, MDMX) 100ul　224081

特徴

• The MDM2 protein is the primary regulator of p53 protein stability.
• MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2.
• The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas.
• ARF interacts with MDMX to sequester MDMX within the nucleolus.
• This sequestration of MDMX by ARF results in an increase in p53 transactivation.
• In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation.
• Like MDM2, MDMX also binds p73 and stabilizes the level of p73.
• Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.