MaxiKbeta subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges.
MaxiKbeta subunit 1, one of four subunits in the MaxiKbeta family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues.
MaxiKbeta subunit 1 associates with MaxiKalpha to form a calcium-activated potassium channel (also designated MaxiK and BK channel).
MaxiKbeta subunit 1 increases the sensitivity of the MaxiKalpha to calcium and voltage.
The MaxiKalpha/beta1 channel is the most sensitive of all Maxi channels to calcium.
MaxiKbeta plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of MaxiKbeta2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 154-203 of Human MaxiKβ2.
