MaxiK channels are large conductance voltage and Ca 2+-activated potassium channels which are formed by tetramers of MaxiKalpha subunits, which create pores that are used for smooth muscle tone and neuronal excitability.
These MaxiKalpha subunits have the ability to coassemble with MaxiKbeta subunits that are structurally related and are able to regulate the function of MaxiKalpha subunits.
KCNMB4 (potassium large conductance calcium-activated channel, subfamily M, beta member 4), also known as Slo-beta-4 or Maxi K channel subunit beta-4, is a 210 amino acid multi-pass membrane protein belonging to the KCNMB family.
Predominantly expressed in brain, KCNMB4 is a regulatory subunit of the calcium activated potassium MaxiKalpha channel.
KCNMB4 contributes to MaxiKalpha channel diversity by modulating calcium sensitivity and gating kinetics of MaxiKalpha.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of MaxiKbeta. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 86-140 of Human MaxiKβ.
