84-2359-85　［取扱停止］MAGED1 (Melanoma-Associated Antigen D1, MAGE Tumor Antigen CCF, MAGE-D1 Antigen, Neurotrophin Receptor-interacting MAGE Homolog, MAGED1, NRAGE, PP2250, PRO2292) 100ul　223994

特徴

• Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells.
• Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis.
• May act as a regulator of the function of DLX family members.
• May regulate TP53/p53 transcriptional activity and inhibit cell proliferation.
• Enhances TP53 phosphorylation and accumulation.
• May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
• Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.