84-2359-41　［取扱停止］LYVE-1 (Cell Surface Retention Sequence-Binding Protein 1, CRSBP 1, CRSBP-1, CRSBP1, Extracellular link Domain Containing 1, Extracellular link Domain-Containing 1, Extracellular link Domain-Containing Protein 1, HAR, hyaluronic acid Receptor, Lymphatic endothelium specific hyaluronan Receptor, lymphatic vessel Endothelial hyaluronan Receptor 1, Lymphatic vessel E ...　223972

特徴

• Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin.
• LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall.
• The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily.
• Like CD44, the LYVE1 molecule binds both soluble and immobilized HA.
• However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.