Ferritin and transferrins manage necessary iron-binding fuctions for iron metabolism.
Transferrins comprise a class of single-chain, two-sited, metal-binding proteins expressed throughout the fluid and cells of vertebrates.
The three major types of transferrin include serotransferrin, lactotransferrin (lactoferrin) and ovotransferrin.
Lactoferrin is found in milk, tears and leukocytes.
It degrades an IgA1 protease secreted by Haemophilus influenzae and, consequently, allows the human IgA1 antibody to effectively abolish Haemophilus influenzae colonization.
Lactoferrin also attenuates the pathogenic potential of Haemophilus influenzae by proteolytic degradation of the Hap adhesin.
While lactoferrin may aid in the the transmission of human T cell leukemia virus type 1, it inhibits HIV-1 replication at the level of viral fusion and entry into cells.
The inhibitory effects of lactoferrin on mixed lymphocyte reactions suggest that it may have the ability to sense the activation status of lymphocytes.
The gene encoding human lactoferrin maps to chromosome 3p21.31.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of LTF. Species Crossreactivity: Human
